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Two‐year‐old female with EBV‐positive diffuse large B‐cell lymphoma and subsequent CNS involvement with neurolymphomatosis
Author(s) -
Bjornard Kari L.,
Leventaki Vasiliki,
Nichols Kim E.,
Sandlund John T.,
Prockop Susan,
Ehrhardt Matthew J.
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27415
Subject(s) - medicine , lymphoma , virus , epstein–barr virus , disease , presentation (obstetrics) , diffuse large b cell lymphoma , immune system , immunology , pathology , surgery
We describe a case of Epstein‐Barr virus (EBV) positive, diffuse large B‐cell lymphoma in a 2‐year‐old female who went on to develop relapsed/refractory central nervous system (CNS) disease, manifesting as cranial nerve neurolymphomatosis. Although her atypical presentation was thought to be associated with an immune deficiency, extensive work‐up was negative. Despite subsequent treatment with third‐party EBV‐specific cytotoxic T‐lymphocytes, she died of progressive disease. This case report raises questions as to whether tailored treatment approaches should be considered for atypical presentations of pediatric lymphoma (e.g., CNS and virus‐associated).