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Burkitt lymphoma in Iraqi children: A distinctive form of sporadic disease with high incidence of EBV + cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation
Author(s) -
Uccini Stefania,
AlJadiry Mazin F.,
Cippitelli Claudia,
Talerico Caterina,
Scarpino Stefania,
AlDarraji Amir F.,
AlBadri Safaa A. F.,
Alsaadawi Adel R.,
AlHadad Salma A.,
Ruco Luigi
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27399
Subject(s) - medicine , incidence (geometry) , lymphoma , disease , expression (computer science) , head (geology) , protein expression , cancer research , pathology , genetics , gene , biology , physics , optics , paleontology , computer science , programming language
Epstein‐Barr virus (EBV)‐related lymphoproliferative disorders are relatively common in Iraqi children. Burkitt lymphoma (BL) accounted for 40% of lymphoma cases. The mean age of 125 BL cases was 5.9 ± 3.1 years, and the male‐to‐female ratio was 3.6:1. Clinical presentation was abdominal in 66% and head and neck in 34%. Bone marrow involvement was higher ( P < 0.001) in children with head and neck disease. Tumor cells had MYC translocation (96%) and were CD20 + /CD10 + /MYC + /BCL2 − . MUM1/IRF4 staining was expressed by a fraction of tumor cells in 19 of 125 cases (15%) and was more frequent ( P < 0.007) in head and neck disease (12/42; 29%). EBV‐encoded RNA was positive in 100 of 125 (80%) BL cases.