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Combined high‐dose intra‐arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma
Author(s) -
Rodriguez Anabel,
Zugbi Santiago,
Requejo Flavio,
Deu Alejandra,
Sampor Claudia,
Sgroi Mariana,
Bosaleh Andrea,
Fandiño Adriana,
Schaiquevich Paula,
Chantada Guillermo
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27385
Subject(s) - medicine , retinoblastoma , carboplatin , topotecan , melphalan , regimen , chemotherapy , ophthalmic artery , surgery , oncology , radiology , biochemistry , chemistry , blood flow , cisplatin , gene
Patients with retinoblastoma and central nervous system (CNS) involvement are rarely curable with available treatments. We designed a high‐dose intra‐arterial regimen targeting the ophthalmic artery and chiasm combined with intrathecal chemotherapy to treat a 4‐year‐old patient with retinoblastoma metastasized to the CNS. After three cycles of this regimen, including carboplatin, melphalan, and intrathecal topotecan, a partial response of the orbital tumor mass and chiasmatic lesion, and complete response in the cerebrospinal fluid and bone marrow were achieved. This new treatment strategy may be explored as a treatment component for patients with overt extraocular retinoblastoma and CNS dissemination.