Combined high‐dose intra‐arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma | Zendy

Rodriguez Anabel | Zendy; Zugbi Santiago | Zendy; Requejo Flavio | Zendy; Deu Alejandra | Zendy; Sampor Claudia | Zendy; Sgroi Mariana | Zendy; Bosaleh Andrea | Zendy; Fandiño Adriana | Zendy; Schaiquevich Paula | Zendy; Chantada Guillermo | Zendy

Premium

Combined high‐dose intra‐arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma

Author(s) -

Rodriguez Anabel,

Zugbi Santiago,

Requejo Flavio,

Deu Alejandra,

Sampor Claudia,

Sgroi Mariana,

Bosaleh Andrea,

Fandiño Adriana,

Schaiquevich Paula,

Chantada Guillermo

Publication year - 2018

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.27385

Subject(s) - medicine , retinoblastoma , carboplatin , topotecan , melphalan , regimen , chemotherapy , ophthalmic artery , surgery , oncology , radiology , biochemistry , chemistry , blood flow , cisplatin , gene

Patients with retinoblastoma and central nervous system (CNS) involvement are rarely curable with available treatments. We designed a high‐dose intra‐arterial regimen targeting the ophthalmic artery and chiasm combined with intrathecal chemotherapy to treat a 4‐year‐old patient with retinoblastoma metastasized to the CNS. After three cycles of this regimen, including carboplatin, melphalan, and intrathecal topotecan, a partial response of the orbital tumor mass and chiasmatic lesion, and complete response in the cerebrospinal fluid and bone marrow were achieved. This new treatment strategy may be explored as a treatment component for patients with overt extraocular retinoblastoma and CNS dissemination.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research