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Can myocardial remodeling be a useful surrogate predictor of myocardial iron load? A 3D echocardiographic multicentric study
Author(s) -
Agha Hala Mounir,
AbdelMassih Antoine Fakhry,
AbdelRahman Mohamed Youssef,
Milanesi Ornella,
Castaldi Biagio,
Geranio Giulia,
Putti Maria Caterina,
Kharabish Ahmed,
Esmail Reem,
ElKamah Ghada,
Hamdy Mona,
ElBaz Heba,
Behairy Noha,
Hanna Carol,
ElTagy Hassan,
Mishriky Mary Atef,
Mamdouh Mirna,
Antonazzo Livio,
Ramadan Tasneem
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27272
Subject(s) - medicine , cardiology , myocardial fibrosis , ventricular remodeling , iron status , cardiac magnetic resonance , fibrosis , heart failure , magnetic resonance imaging , iron deficiency , anemia , radiology
The relationship between myocardial iron load and eccentric myocardial remodeling remains an under‐investigated area; it was thought that remodeling is rather linked to fibrosis. This study aims to determine whether or not measures of remodeling can be used as predictors of myocardial iron. For this purpose, 60 patients with thalassemia were studied with 3D echocardiography and myocardial relaxometry (T2*) by Cardiac MRI. 3D derived sphericity index was significantly higher in patients with myocardial iron load. It was correlated with T2* with a 100% sensitivity and specificity (cut‐off value of 0.34) to discriminate between patients with and without myocardial iron overload.