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Sudden spinal hemorrhage in a pediatric case with total body irradiation‐induced cavernous hemangioma
Author(s) -
Mikami Takashi,
Kato Itaru,
Nozaki Fumihito,
Umeda Katsutsugu,
Kamitori Tatsuya,
Tasaka Keiji,
Ogata Hideto,
Hiramatsu Hidefumi,
Arakawa Yoshiki,
Adachi Souichi
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27250
Subject(s) - medicine , hemangioma , magnetic resonance imaging , total body irradiation , regimen , surgery , adverse effect , radiation therapy , radiology , chemotherapy , cyclophosphamide
Compared to cerebral radiation‐induced cavernous hemangiomas (RICHs), little is known about intraspinal RICHs. A 13‐year‐old male suddenly developed symptomatic spinal hemorrhage eight years after hematopoietic stem cell transplantation using a total body irradiation (TBI) based myeloablative regimen. A solitary small hemangioma was detected on follow‐up T2 star weighted magnetic resonance imaging of the spine. His neurological symptoms gradually improved with supportive treatment and rehabilitation, although he experienced rebleeding 2 years later. Intraspinal RICH is very rare but should be recognized as a possible late adverse effect in pediatric patients who received TBI.