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Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study
Author(s) -
Raghubar Kimberly P.,
Lamba Michael,
Cecil Kim M.,
Yeates Keith Owen,
Mahone E. Mark,
Limke Christina,
Grosshans David,
Beckwith Travis J.,
Ris M. Douglas
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27245
Subject(s) - medicine , neurocognitive , brain size , metric (unit) , neuropsychology , hippocampus , radiation therapy , cognition , nuclear medicine , radiology , operations management , psychiatry , magnetic resonance imaging , economics
Background Advances in radiation treatment (RT), specifically volumetric planning with detailed dose and volumetric data for specific brain structures, have provided new opportunities to study neurobehavioral outcomes of RT in children treated for brain tumor. The present study examined the relationship between biophysical and physical dose metrics and neurocognitive ability, namely learning and memory, 2 years post‐RT in pediatric brain tumor patients. Procedure The sample consisted of 26 pediatric patients with brain tumor, 14 of whom completed neuropsychological evaluations on average 24 months post‐RT. Prescribed dose and dose–volume metrics for specific brain regions were calculated including physical metrics (i.e., mean dose and maximum dose) and biophysical metrics (i.e., integral biological effective dose and generalized equivalent uniform dose). We examined the associations between dose–volume metrics (whole brain, right and left hippocampus), and performance on measures of learning and memory (Children's Memory Scale). Results Biophysical dose metrics were highly correlated with the physical metric of mean dose but not with prescribed dose. Biophysical metrics and mean dose, but not prescribed dose, correlated with measures of learning and memory. Conclusions These preliminary findings call into question the value of prescribed dose for characterizing treatment intensity; they also suggest that biophysical dose has only a limited advantage compared to physical dose when calculated for specific regions of the brain. We discuss the implications of the findings for evaluating and understanding the relation between RT and neurocognitive functioning.