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Pediatric superior vena cava syndrome: An evidence‐based systematic review of the literature
Author(s) -
Nossair Fadi,
Schoettler Peter,
Starr Joanne,
Chan Anthony K. C.,
Kirov Ivan,
Paes Bosco,
Mahajerin Arash
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27225
Subject(s) - medicine , superior vena cava syndrome , thrombosis , presentation (obstetrics) , intensive care medicine , pediatrics , superior vena cava , surgery
Superior vena cava syndrome (SVCS) results in vascular, respiratory, and neurologic compromise. A systematic search was conducted to determine the prevalence of pediatric SVCS subtypes and identify clinical characteristics/treatment strategies that may influence overall outcomes. Data from 101 case reports/case series (142 patients) were analyzed. Morbidity (30%), mortality (18%), and acute complications (55%) were assessed as outcomes. Thrombosis was present in 36%, with multi‐modal anticoagulation showing improved outcome by >50% ( P = 0.004). Infant age ( P = 0.04), lack of collaterals ( P = 0.007), acute complications ( P = 0.005), and clinical presentation may have prognostic utility that could influence clinical decisions and surveillance practices in pediatric SVCS.