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Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment
Author(s) -
Mylonas Konstantinos S.,
Doulamis Ilias P.,
Tsilimigras Diamantis I.,
Nasioudis Dimitrios,
Schizas Dimitrios,
Masiakos Peter T.,
Kelleher Cassandra M.
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.27114
Subject(s) - medicine , radiation therapy , neuroendocrine tumors , pancreaticoduodenectomy , chemotherapy , adjuvant radiotherapy , oncology , adjuvant chemotherapy , pancreas , cancer , breast cancer
Abstract A systematic review of 32 studies reporting on 489 children with pancreatic tumors was performed. The most prevalent histologic subtype was solid pseudopapillary tumor (SPT) (61.3%). Pancreaticoduodenectomy was the most commonly performed operation (48%). Neoadjuvant chemo/radiotherapy was utilized in 3.9, 36.2, 25, and 27.8% of patients with SPTs, pancreatoblastomas (PBLs), neuroendocrine tumors, and exocrine carcinomas, respectively. Adjuvant chemotherapy (75.6%) and radiation (34%) were most commonly utilized in PBLs. All‐cause mortality was highest in exocrine carcinomas (50%). Overall, 98.8% of patients with SPTs survived. PBL exhibited the highest recurrence rate (14.7%) within a mean of 23.5 months.