Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn | Zendy

Levitt Rebecca N. | Zendy; Gourri Elise | Zendy; Gassner Christoph | Zendy; BanezSese Grace | Zendy; Salam Abdus | Zendy; Denomme Gregory A. | Zendy; Yang Elizabeth | Zendy

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Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn

Author(s) -

Levitt Rebecca N.,

Gourri Elise,

Gassner Christoph,

BanezSese Grace,

Salam Abdus,

Denomme Gregory A.,

Yang Elizabeth

Publication year - 2018

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.27014

Subject(s) - medicine , phenotype , immunology , obligate , glycophorin , disease , antibody , fetus , red blood cell , antigen , heterozygote advantage , gene , pregnancy , genetics , biology , allele , ecology

Gerbich (Ge) antigens are high frequency red cell antigens expressed on glycophorin C (GYPC) and glycophorin D. Hemolytic disease of the fetus and newborn (HDFN) due to Gerbich antibody is rare and presents a clinical challenge, as Gerbich negative blood is scarce. We report a case of HDFN due to maternal Ge3 negative phenotype and anti‐Ge3 alloimmunization, successfully managed by transfusion of maternal blood. Molecular testing revealed that the mother has homozygous deletion of exon 3 of GYPC , the father is homozygous wildtype for GYPC , and the infant is obligate heterozygote expressing Ge3.

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