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Musculoskeletal complications following total body irradiation in hematopoietic stem cell transplant patients
Author(s) -
Jackson Taylor J.,
MostoufiMoab Sogol,
HillKayser Christine,
Balamuth Naomi J.,
Arkader Alexandre
Publication year - 2018
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26905
Subject(s) - medicine , total body irradiation , hematopoietic stem cell transplantation , surgery , slipped capital femoral epiphysis , stem cell , transplantation , cyclophosphamide , chemotherapy , femoral head , biology , genetics
Total body irradiation (TBI) is commonly used in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) to treat benign and malignant disease. Though life‐saving, these therapies place patients at risk for important side effects, including musculoskeletal complications such as short stature, osteonecrosis, slipped capital femoral epiphysis, and the development of benign and malignant bone tumors. With an increasing number of HSCT survivors, there is a growing need for awareness of the musculoskeletal complications of HSCT and TBI.