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Clinical case series of pediatric hepatic angiosarcoma
Author(s) -
Grassia Kalee L.,
Peterman Caitlin M.,
Iacobas Ionela,
Margolin Judith F.,
Bien Ewa,
Padhye Bhavna,
Meyers Rebecka L.,
Adams Denise M.
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26627
Subject(s) - medicine , angiosarcoma , series (stratigraphy) , radiology , pediatrics , paleontology , biology
Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a “vascular tumor.” Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low‐grade form of angiosarcoma rather than a benign lesion.