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Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort
Author(s) -
Mogensen Signe Sloth,
HarilaSaari Arja,
Frandsen Thomas Leth,
Lähteenmäki Päivi,
Castor Anders,
Kohonen Ia,
Schmiegelow Kjeld,
Mäkitie Outi
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26624
Subject(s) - medicine , lymphoblastic leukemia , presentation (obstetrics) , pediatrics , cohort , acute leukemia , leukemia , surgery
Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.