Premium
Failure of MIBG scan to detect metastases in SDHB‐mutated pediatric metastatic pheochromocytoma
Author(s) -
Sait Sameer,
PanditTaskar Neeta,
Modak Shakeel
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26549
Subject(s) - sdhb , paraganglioma , pheochromocytoma , medicine , neuroblastoma , positron emission tomography , nuclear medicine , radiology , germline mutation , pathology , mutation , chemistry , biology , biochemistry , genetics , gene , cell culture
Abstract 123 I‐meta‐iodo benzyl guanidine (MIBG) scans are considered the gold standard imaging in neuroblastoma; however, flouro deoxy glucose positron emission tomography (FDG‐PET) scans have increased sensitivity in adults with pheochromocytoma/paraganglioma. We describe a pediatric patient initially considered to have localized neuroblastoma based on anatomical imaging and 123 I‐MIBG scan, but subsequent investigations revealed germline succinate dehydrogenase complex iron sulfur subunit B (SDHB) mutation–associated pheochromocytoma with multiple FDG‐avid skeletal metastases. We then compared 123 I‐MIBG and FDG‐PET scans in children with metastatic pheochromocytoma/paraganglioma. FDG‐PET was superior to 123 I‐MIBG scan for the detection of skeletal metastases (median number of skeletal lesions detected 10 [range 1–30] vs. 2 [range 1–26], respectively; P = 0.005 by t‐test). FDG‐PET should be considered the functional scan of choice in children with pheochromocytoma/paraganglioma.