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Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS
Author(s) -
Osumi Tomoo,
Kato Motohiro,
OuchiUchiyama Meri,
Tomizawa Daisuke,
Kataoka Keisuke,
Fujii Yoichi,
Seki Masafumi,
Takita Junko,
Ogawa Seishi,
Uchiyama Toru,
Ohki Kentaro,
Kiyokawa Nobutaka
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26496
Subject(s) - juvenile myelomonocytic leukemia , kras , transformation (genetics) , cancer research , medicine , allele , mutant , leukemia , malignant transformation , mutation , genetics , biology , gene , stem cell , haematopoiesis
Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.