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Ascitic fluid drainage using a peritoneal dialysis catheter to prevent and treat multi‐organ dysfunction in veno‐occlusive disease in children undergoing hematopoietic stem cell transplantation
Author(s) -
Parmar Vijal,
Lewis Malcolm,
Shenoy Mohan,
Bonney Denise,
Wynn Robert
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26469
Subject(s) - medicine , peritoneal dialysis , hematopoietic stem cell transplantation , hepatic veno occlusive disease , transplantation , surgery , dialysis , disease , stem cell , intensive care medicine , biology , genetics
Veno‐occlusive disease (VOD), or sinusoidal obstruction syndrome, is a well‐recognised, serious complication associated with the chemotherapy conditioning therapy used in hematopoietic stem cell transplantation (HSCT). Fluid management is typically challenging in children with this condition. We describe effective early use of peritoneal dialysis catheters to drain extravascular, intra‐abdominal fluid in children with VOD, allowing intravascular fluid administration to preserve renal perfusion and function, preventing multi‐organ dysfunction. All but one of the children are long‐term survivors, both of their significant VOD and their HSCT. The child that did not survive died from their underlying metabolic illness, not VOD.