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Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement
Author(s) -
Ranta Susanna,
Palomäki Maarit,
Levinsen Mette,
Taskinen Mervi,
Abrahamsson Jonas,
Hasle Henrik,
Jahnukainen Kirsi,
Heyman Mats,
HarilaSaari Arja
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26459
Subject(s) - medicine , central nervous system , myeloid leukemia , neuroimaging , cerebrospinal fluid , palsy , leukemia , myeloid , pathology , pediatrics , psychiatry , alternative medicine
Central nervous system (CNS) involvement in childhood acute myeloid leukemia (AML) can manifest as leukemic cells in the cerebrospinal fluid, a solid CNS tumor, or as neurological symptoms. We evaluated the presenting symptoms and neuroimaging findings in 33 of 34 children with AML and CNS involvement at diagnosis in the period 2000–2012 in Sweden, Finland, and Denmark. Imaging was performed in 22 patients, of whom 16 had CNS‐related symptoms. Seven patients, including all but two with facial palsy, had mastoid cell opacification, considered an incidental finding. The frequent involvement of the mastoid bone with facial palsy warrants evaluation in larger series.