A man‐made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother | Zendy

Barg Assaf Arie | Zendy; Ifrah Aviya Dvir | Zendy; Strauss Tzipi | Zendy; Simchen Michal J. | Zendy; Orvieto Raoul | Zendy; Rosenberg Nurit | Zendy; Kenet Gili | Zendy

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A man‐made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Author(s) -

Barg Assaf Arie,

Ifrah Aviya Dvir,

Strauss Tzipi,

Simchen Michal J.,

Orvieto Raoul,

Rosenberg Nurit,

Kenet Gili

Publication year - 2017

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.26447

Subject(s) - medicine , fetus , pregnancy , disease , obstetrics , gestational age , genetics , biology

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

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