Premium
Sinusoidal CD30+ diffuse large B‐cell lymphoma can masquerade as anaplastic large cell lymphoma in pediatric posttransplant lymphoproliferative disorders
Author(s) -
Bhatt Neel S.,
Kelly Michael E.,
Batdorf Bjorn,
Gheorghe Gabriela
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26403
Subject(s) - medicine , cd30 , anaplastic large cell lymphoma , lymphoma , lymphoproliferative disorders , anaplastic lymphoma kinase , pathology , rituximab , diffuse large b cell lymphoma , post transplant lymphoproliferative disorder , transplantation , chemotherapy , large cell , organ transplantation , cancer , adenocarcinoma , malignant pleural effusion , lung cancer
Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. Diffuse large B‐cell lymphoma (DLBCL) is frequently seen in this setting. However, CD30+ DLBCL with sinusoidal pattern of involvement has not been reported in pediatric PTLD. We are reporting a 9‐year‐old female child presented with diffuse lymphadenopathy postheart transplantation. The pattern of involvement was suggestive of anaplastic large cell lymphoma, but the malignant cells were positive for B‐cell markers and negative for anaplastic lymphoma kinase. The patient was treated aggressively with multiagent chemotherapy and rituximab. Accurate diagnosis in PTLD is paramount in making management decisions.