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Successful treatment of mature B‐cell lymphoma with rituximab‐based chemotherapy in a patient with Bloom syndrome
Author(s) -
Jastaniah Wasil
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26385
Subject(s) - medicine , rituximab , chemotherapy , lymphoma , oncology
This report presents a case of Bloom syndrome (BS) in a consanguineous Saudi family. The patient, an 11‐year‐old male with mature B‐cell lymphoma, had minimal therapeutic response and significant dose‐limiting toxicity with standard chemotherapy treatment. He later responded successfully to a rituximab‐based chemotherapy protocol. This case highlights that the rituximab‐based chemotherapy protocol is an effective and safe treatment alternative for mature B‐cell lymphoma in patients with BS. Further trials are warranted to investigate this modality of treatment.