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The effect of maternal and infant factors on cord blood yield
Author(s) -
Mousavi Seyed Hadi,
Abroun Saeid,
Zarrabi Morteza,
Ahmadipanah Mona
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26381
Subject(s) - medicine , umbilical cord , cord blood , transplantation , haematopoiesis , hematopoietic stem cell transplantation , cd34 , malignancy , umbilical cord blood transplantation , hematopoietic cell , stem cell , immunology , obstetrics , oncology , biology , genetics
Umbilical cord blood (CB) can be used as an alternative hematopoietic stem cell source for transplantation in hematological malignancy and blood disorders. The success of transplantation is highly related to the levels of total nucleated cell and CD34 + cell counts. The evaluation of optimal conditions can decrease the rate of graft rejection due to low cell count and increases the quality of CB units (CBUs) in the blood bank and the success rate of engraftment. To this end, we review the maternal and infant parameters affecting the quality and quantity of CBUs.