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Angiomatoid fibrous histiocytoma: A case of local recurrence and metastases to loco‐regional lymph nodes that responded to chemotherapy
Author(s) -
Ogden Sally,
Harave Srikrishna,
McPartland Jo,
Brennan Bernadette,
Jeys Lee,
Losty Paul,
Pizer Barry
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26376
Subject(s) - medicine , ifosfamide , chemotherapy , lymph node , doxorubicin , lymph , surgical excision , radiology , surgery , pathology , cisplatin
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour with intermediate malignant potential. We report the case of a patient with local recurrence of AFH in two locations and lymph node metastases 18 months after primary surgical excision. The patient was treated with six cycles of ifosfamide and doxorubicin chemotherapy and a further three courses of ifosfamide monotherapy. Reassessment imaging showed a good response to chemotherapy with reduction in size of the two tumours of local recurrence and the lymph node metastases. This case demonstrates that AFH can respond to chemotherapy, even though it is rarely used.