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Lupus anticoagulant hypoprothrombinemia syndrome associated with severe thrombocytopenia in a child
Author(s) -
Foord Aimee,
Baca Nicole,
Buchbinder David,
Mahajerin Arash
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26357
Subject(s) - hypoprothrombinemia , medicine , lupus anticoagulant , hydroxychloroquine , systemic lupus erythematosus , anticoagulant , antiphospholipid syndrome , partial thromboplastin time , immunology , pediatrics , dermatology , gastroenterology , antibody , platelet , disease , vitamin k , covid-19 , infectious disease (medical specialty)
Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) comprises lupus anticoagulant, acquired hypoprothrombinemia, and often mild thrombocytopenia or normal platelets. It is usually associated with autoimmunity or postviral illness. We describe a case of a 10‐year‐old boy with oral bleeding and severe thrombocytopenia initially suggestive of immune thrombocytopenia. Secondary to bleeding, evaluation demonstrated prolonged coagulation tests and subsequently revealed the presence of lupus anticoagulant and hypoprothrombinemia, along with marked autoimmunity, suggestive of LAHPS. He was treated with intravenous immunoglobulin and hydroxychloroquine. This case report and discussion highlight the diagnostic and therapeutic challenges associated with LAHPS and coincident severe thrombocytopenia.