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Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction
Author(s) -
Hiniker Susan M.,
Rangaswami Arun,
Lungren Matthew P.,
Thakor Avnesh S.,
Concepcion Waldo,
Balazy Kathleen E.,
Kovalchuk Nataliya,
Donaldson Sarah S.
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26330
Subject(s) - medicine , hepatocellular carcinoma , radiation therapy , radiology , chemotherapy , liver disease
Here, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0–4.3 mg/dl despite placement of bilateral internal–external biliary drains. The tumor was not resectable, and the patient was not a candidate for liver transplant due to nodal disease, for chemotherapy due to hyperbilirubinemia, or for local therapies aside from stereotactic body radiotherapy (SBRT). In this report, we discuss the successful use of SBRT in the management of this patient, and its role in allowing the patient to become a candidate for additional therapies.