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Hepatocellular adenoma among adult survivors of childhood and young adult cancer
Author(s) -
Tonorezos Emily S.,
Barnea Dana,
AbouAlfa Ghassan K.,
Bromberg Jacqueline,
D'Angelica Michael,
Sklar Charles A.,
Shia Jinru,
Oeffinger Kevin C.
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26294
Subject(s) - medicine , hepatocellular adenoma , young adult , incidence (geometry) , neoplasm , cancer , hepatocellular carcinoma , oncology , pediatrics , malignant transformation , childhood cancer , adenoma , family history , pathology , physics , optics
Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified 12 cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N = 4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All 11 females had prior estrogen therapy; the male case was hypogonadal. This report suggests childhood and young adult cancer survivors may be at increased risk for HCA, but further investigation is needed.