Outcomes of children with rhabdomyosarcoma treated with intensive chemotherapy, surgery, and radiotherapy through a period of protocol revision at a South African center, 1990–2010 | Zendy

Hendricks Marc | Zendy; Parkes Jeanette | Zendy; Pillay Komala | Zendy; Millar Alastair | Zendy; Eyssen Ann | Zendy; Numanoglu Alp | Zendy; Davidson Alan | Zendy

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Outcomes of children with rhabdomyosarcoma treated with intensive chemotherapy, surgery, and radiotherapy through a period of protocol revision at a South African center, 1990–2010

Author(s) -

Hendricks Marc,

Parkes Jeanette,

Pillay Komala,

Millar Alastair,

Eyssen Ann,

Numanoglu Alp,

Davidson Alan

Publication year - 2017

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.26248

Subject(s) - medicine , rhabdomyosarcoma , radiation therapy , stage (stratigraphy) , overall survival , cohort , chemotherapy , surgery , biopsy , pediatrics , sarcoma , pathology , paleontology , biology

A total of 75 children with biopsy‐proven rhabdomyosarcoma were treated at our institution between 1990 and 2010. Five‐year overall survival (OS) for the entire cohort was 58.7%. OS by stage was as follows: Stage 1 (80%), Stage 2 (80%), Stage 3 (54.1%), and Stage 4 (38.5%). There was a trend to suggest that revision of treatment approaches improved crude survival over time: pre‐2003 (OS 42.1%); 2003–2005 (OS 50.0%); 2005–2010 (OS 60.8%).

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