Premium
IFR4/MUM1‐positive lymphoma in Waldeyer ring with co‐expression of CD5 and CD10
Author(s) -
Chen Lei,
AlKzayer Lika'a Fasih Y.,
Liu Tingting,
Kobayashi Norimoto,
Nakazawa Yozo,
Koike Kenichi
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26236
Subject(s) - lymphoma , germinal center , cd5 , medicine , pathology , immunohistochemistry , irf4 , cancer research , b cell , antibody , immunology , biology , transcription factor , gene , genetics
IRF4/MUM1‐positive lymphoma is a new subgroup of germinal center‐derived B‐cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7‐year‐old Chinese male with B‐cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1‐positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1‐positive lymphoma in WR with co‐expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.