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Sclerosing cholangitis and intracranial lymphoma in a child with classical Wiskott–Aldrich syndrome
Author(s) -
Vignesh Pandiarajan,
Suri Deepti,
Rawat Amit,
Lau Yu Lung,
Bhatia Anmol,
Das Ashim,
Srinivasan Anirudh,
Dhandapani Sivashanmugam
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26196
Subject(s) - medicine , wiskott–aldrich syndrome , lymphoma , malignancy , pathology , magnetic resonance imaging , histopathology , pneumonia , radiology , biochemistry , chemistry , gene
Patients with Wiskott–Aldrich syndrome (WAS) are predisposed to malignancy and autoimmunity in addition to infections. We report a male child with WAS, who had presented with recurrent pneumonia, eczema, thrombocytopenia, autoimmune hemolytic anemia, and vasculitic skin lesions. Genetic analysis revealed a classical genotype WAS 155C>T; R41X. At 2 years of follow‐up, he developed persistent headache and progressive hepatomegaly. Brain imaging showed a mass in the right frontal region, which on histopathology was shown to be high‐grade non‐Hodgkin lymphoma. Magnetic resonance cholangiopancreatography showed features of sclerosing cholangitis. This report extends the clinical spectrum and highlights unusual manifestations of sclerosing cholangitis and intracranial lymphoma in a patient with WAS.