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Atypical teratoid/rhabdoid tumor arising in a malignant glioma
Author(s) -
Bozzai Barbara,
Hasselblatt Martin,
Turányi Eszter,
Frühwald Michael C.,
Siebert Reiner,
Bens Susanne,
Schneppenheim Reinhard,
Kool Marcel,
Stelczer Gábor,
Hortobágyi Tibor,
Hauser Peter
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26173
Subject(s) - medicine , atypical teratoid rhabdoid tumor , temozolomide , bevacizumab , malignancy , glioma , biopsy , brain tumor , glioblastoma , pathology , oncology , immunohistochemistry , chemotherapy , cancer research
Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.