Atypical teratoid/rhabdoid tumor arising in a malignant glioma | Zendy

Bozzai Barbara | Zendy; Hasselblatt Martin | Zendy; Turányi Eszter | Zendy; Frühwald Michael C. | Zendy; Siebert Reiner | Zendy; Bens Susanne | Zendy; Schneppenheim Reinhard | Zendy; Kool Marcel | Zendy; Stelczer Gábor | Zendy; Hortobágyi Tibor | Zendy; Hauser Peter | Zendy

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Atypical teratoid/rhabdoid tumor arising in a malignant glioma

Author(s) -

Bozzai Barbara,

Hasselblatt Martin,

Turányi Eszter,

Frühwald Michael C.,

Siebert Reiner,

Bens Susanne,

Schneppenheim Reinhard,

Kool Marcel,

Stelczer Gábor,

Hortobágyi Tibor,

Hauser Peter

Publication year - 2017

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.26173

Subject(s) - medicine , atypical teratoid rhabdoid tumor , temozolomide , bevacizumab , malignancy , glioma , biopsy , brain tumor , glioblastoma , pathology , oncology , immunohistochemistry , chemotherapy , cancer research

Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.

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