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Underlying undiagnosed inherited marrow failure syndromes among children with cancer
Author(s) -
Alabbas Fahad,
Weitzman Sheila,
Grant Ronald,
Bouffet Eric,
Malkin David,
Abla Oussama,
Dror Yigal
Publication year - 2017
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26120
Subject(s) - medicine , pediatric cancer , cancer , bone marrow failure , blood cancer , pediatrics , medical record , prospective cohort study , intensive care medicine , stem cell , haematopoiesis , biology , genetics
To study the prevalence of pediatric cancer patients who have underlying inherited bone marrow failure syndrome (IBMFS), we retrospectively reviewed the medical records of newly diagnosed pediatric cancer patients at The Hospital for Sick Children from June 2009 to May 2010, focusing on clinical, laboratory, and treatment‐related findings which may indicate underlying IBMFS. We found five (1.8%) patients out of 276 who had two or more findings suggestive of IBMFS. We conclude that a small fraction of patients with cancer have clinical features that indicate investigations to rule out underlying IBMFSs. A prospective study is needed to determine their prevalence.