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Primary Cutaneous Lymphomas in Children and Adolescents
Author(s) -
Ceppi Francesco,
Pope Elena,
Ngan Bo,
Abla Oussama
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26076
Subject(s) - medicine , mycosis fungoides , pathological , cd30 , lymphoproliferative disorders , lymphoma , dermatology , pathology
Primary cutaneous lymphomas are rare in children and mostly represented by mycosis fungoides and CD30 + lymphoproliferative disorders. Most pediatric cutaneous lymphomas have similar clinical/pathological features as their adult counterparts, particularly the T‐cell subtypes. With regard to outcome, adult cutaneous mature T‐cell lymphomas have a tendency to progression, while this appears to be relatively infrequent in children. The outcome of cutaneous B‐cell lymphomas depends on subtype, with the B‐lymphoblastic entity being associated with similar outcomes to precursor B acute lymphoblastic leukemia, while there are insufficient data on other entities. The diagnosis and treatment of these patients require a close collaboration between experienced pediatric pathologists, dermatologists, and oncologists. Prospective collection of longitudinal clinical and biological data from children with these rare lymphomas is needed to better understand their biological and clinical behavior and to ultimately discover the best therapeutic strategies.