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Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B‐cell Compartment
Author(s) -
Koskenvuo Minna,
Ekman Ilse,
Saha Emmi,
Salokannel Ellinoora,
Matomäki Jaakko,
Ilonen Jorma,
Kainulainen Leena,
Arola Mikko,
Lähteenmäki Päivi Maria
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26047
Subject(s) - medicine , lymphoblastic leukemia , compartment (ship) , antibody , chemotherapy , immune system , immunology , leukemia , humoral immunity , immunity , lymphocyte , b cell , oceanography , geology
Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard‐risk (SR) or intermediate‐risk (IR) acute lymphoblastic leukemia (ALL). Both naïve and memory B cells were most severely affected and showed slow recovery during the 2‐year follow‐up, while the T‐cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine‐preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B‐cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function.