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Patterns of Failure for Pediatric Glioblastoma Multiforme Following Radiation Therapy
Author(s) -
Shabason Jacob E.,
Sutton David,
Kenton Owen,
Guttmann David M.,
Lustig Robert A.,
HillKayser Christine
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.26031
Subject(s) - medicine , glioblastoma , radiation therapy , retrospective cohort study , disease , adjuvant therapy , adjuvant radiotherapy , multimodal therapy , pediatrics , oncology , chemotherapy , cancer research
Despite aggressive multimodal therapy for pediatric glioblastoma multiforme (GBM), patient survival remains poor. This retrospective review of patients with GBM aims to evaluate the patterns of failure after radiation therapy (RT). The study included 14 pediatric patients treated with RT at the Children's Hospital of Philadelphia from 2007 to 2015. With a median follow‐up of 16.9 months, 13 (92.9%) developed recurrent disease. Of recurrences, nine (69.2%) were in‐field, three (23.1%) were marginal, and one (7.7%) was distant. The majority of patients treated with adjuvant radiation failed in the region of high‐dose RT, indicating the need for improvements in local therapy.