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Persistent Multiyear Control of Relapsed T‐Cell Acute Lymphoblastic Leukemia With Successive Donor Lymphocyte Infusions: A Case Report
Author(s) -
Huo Jeffrey S.,
Symons Heather J.,
Robey Nancy,
Borowitz Michael J.,
Schafer Eric S.,
Chen Allen R.
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25971
Subject(s) - medicine , hematopoietic stem cell transplantation , minimal residual disease , lymphoblastic leukemia , stem cell , leukemia , sibling , disease , transplantation , oncology , lymphocyte , graft versus host disease , immunology , psychology , developmental psychology , biology , genetics
There are few therapeutic options for patients with T‐cell acute lymphoblastic leukemia (T‐ALL) who have recurrent disease after initial matched sibling hematopoietic stem cell transplantation. While a second hematopoietic stem cell transplant (HSCT) from a haploidentical donor offers the conceptual possibility of greater graft versus leukemia effect, there is minimal literature to describe the efficacy of this approach in recurrent pediatric T‐ALL. We present the case of a now 9‐year‐old female in whom second haploidentical HSCT, followed by successive donor lymphocyte infusions in response to minimal residual disease reemergence, has led to 3+ years of ongoing disease control without graft versus host disease and excellent quality of life.