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Central Diabetes Insipidus and Cisplatin‐Induced Renal Salt Wasting Syndrome: A Challenging Combination
Author(s) -
Cortina Gerard,
Hansford Jordan R.,
Duke Trevor
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25910
Subject(s) - medicine , polyuria , diabetes insipidus , sequela , hyponatremia , polydipsia , cisplatin , nephrogenic diabetes insipidus , natriuresis , pediatrics , diabetes mellitus , endocrinology , surgery , kidney , chemotherapy
We describe a 2‐year‐old female with a suprasellar primitive neuroectodermal tumor and central diabetes insipidus (DI) who developed polyuria with natriuresis and subsequent hyponatremia 36 hr after cisplatin administration. The marked urinary losses of sodium in combination with a negative sodium balance led to the diagnosis of cisplatin‐induced renal salt wasting syndrome (RSWS). The subsequent clinical management is very challenging. Four weeks later she was discharged from ICU without neurological sequela. The combination of cisplatin‐induced RSWS with DI can be confusing and needs careful clinical assessment as inaccurate diagnosis and management can result in increased neurological injury.