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Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant
Author(s) -
Lapadat Razvan,
Tower Richard L.,
Tam Wayne,
Orazi Attilio,
Gheorghe Gabriela
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25898
Subject(s) - medicine , myeloid sarcoma , sarcoma , differential diagnosis , myeloid leukemia , pathology , myeloid , leukemia , primitive neuroectodermal tumor , ewing's sarcoma , presentation (obstetrics) , immunohistochemistry , cancer research , immunology , radiology
Pure erythroid leukemia (PEL) is a rare type of acute myeloid leukemia (AML) with a very aggressive clinical course. Presentation as a myeloid/erythroid sarcoma is exceedingly rare. We describe an infantile PEL presenting as a multifocal myeloid sarcoma, clinically and pathologically mimicking Ewing sarcoma/PNET family of tumors. The patient died 8 weeks after the initial presentation due to widespread disease. Our case shows that PEL needs to be considered in the differential diagnosis of small round blue cell tumors in infancy. A meticulous workup including immunohistochemistry, flow cytometry, molecular, and cytogenetic studies was required to reach the diagnosis.