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Breast Cancer and Non‐Hodgkin Lymphoma in a Young Male with Cowden Syndrome
Author(s) -
Hagelstrom Robert Tanner,
Ford James,
Reiser Gwendolyn M.,
Nelson Marilu,
Pickering Diane L.,
Althof Pamela A.,
Sanger Warren G.,
Coccia Peter F.
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25796
Subject(s) - medicine , cowden syndrome , pten , breast cancer , tensin , lymphoma , cancer , oncology , cancer syndrome , malignancy , germline mutation , gene , mutation , genetics , pi3k/akt/mtor pathway , apoptosis , biology
Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2 ); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [ PTEN ] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B‐cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.