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Successful Unrelated Stem Cell Transplantation in an Infant With Congenital Acute Myelogenous Leukemia FAB M5 Showing Massive Cutaneous Infiltrations—A Challenging Multidisciplinary Approach
Author(s) -
Lanz Sofia,
Schwinger Wolfgang,
Sovinz Petra,
Lackner Herwig,
Resch Bernhard,
Urlesberger Berndt,
Sipurzynski Sabine,
Urban Christian
Publication year - 2016
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25703
Subject(s) - medicine , leukemia , multidisciplinary approach , transplantation , stem cell , lymphoblastic leukemia , immunology , biology , genetics , social science , sociology
The multidisciplinary management of a male neonate presenting with congenital acute myelogenous leukemia of monoblastic phenotype is reported using conventional chemotherapy, high dose conditioning, and matched unrelated donor stem cell transplantation. These therapies were combined to add a graft versus leukemia effect to the treatment. Although chimerism studies showed a decrease of donor white blood cells, T‐cells remained stable of allogeneic origin. We hypothesize that a continuous graft versus leukemia effect results in minimal residual disease negativity for now more than 18 months since stem cell transplantation. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.