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Intra‐Arterial Platelet Infusion for Intractable Hemorrhage and Refractory
Author(s) -
Kably Issam M.,
Ziga Edward D.,
Andreansky Martin
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25633
Subject(s) - medicine , refractory (planetary science) , platelet , gastrointestinal bleeding , surgery , salvage therapy , gastrointestinal cancer , platelet transfusion , cancer , chemotherapy , colorectal cancer , physics , astrobiology
Acute gastrointestinal graft‐versus‐host disease (GVHD) refractory to first‐line treatment with systemic corticosteroids results in increased morbidity and potential mortality. We retrospectively assessed the feasibility and efficacy of catheter‐directed intra‐arterial platelet infusion (IAPI) in two pediatric patients with steroid and transfusion refractory gastrointestinal GVHD causing intractable lower gastrointestinal hemorrhage and refractory thrombocytopenia, that were referred for salvage therapy. Immediate angiographic response was noted with a resolution of hemorrhage and decreased blood requirements. We reviewed the literature regarding this treatment modality and compared it to the available minimally invasive transcatheter techniques to control gastrointestinal hemorrhage. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.