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Subcutaneous panniculitis‐like T‐cell lymphoma: Pediatric case series demonstrating heterogeneous presentation and option for watchful waiting
Author(s) -
Johnston Emily E.,
LeBlanc Robert E.,
Kim Jinah,
Chung Jong,
Balagtas Jay,
Kim Youn H.,
Link Michael P.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25626
Subject(s) - medicine , panniculitis , watchful waiting , lymphoma , dermatology , pathology , cancer , prostate cancer
Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) and primary cutaneous gamma delta T‐cell lymphoma (PCGD‐TCL) were initially both classified as subcutaneous panniculitis‐like T‐cell lymphoma. In 2008, SPTCL with alpha‐beta T‐cell receptor subtype was separated from primary cutaneous gamma delta T‐cell lymphomas (PCGD‐TCL). We report four pediatric cases that demonstrate the heterogeneity of each disease and show that PCGD‐TCL in children can have an indolent course, whereas SPTCL can behave aggressively. Three patients had spontaneous, durable remissions without treatment, whereas the one patient with disease progression was treated successfully. Watchful waiting may thus be appropriate for initial management of children. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.