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Caution is recommended prior to sildenafil use in vascular anomalies
Author(s) -
Rankin Hannah,
Zwicker Kelley,
Trenor Cameron C.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25600
Subject(s) - sildenafil , medicine , vascular disease , pulmonary hypertension , vascular malformation , intensive care medicine , cardiology , surgery , pediatrics
Since publication of a single case report of lymphatic malformation improvement during sildenafil therapy for pulmonary hypertension, sildenafil use has propagated across multiple vascular anomalies diagnoses. Vascular anomalies are rare conditions, often with poor long‐term outcomes from available therapies, making these patients vulnerable to novel therapy use. We have retrospectively reviewed 14 children with vascular anomalies treated with sildenafil. None of these patients reported improvement of disease while on treatment and some reported side effects including infections and bleeding. Pending more convincing prospective data, we recommend caution prior to sildenafil use for vascular anomalies. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.