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Fulminant skin GvHD with a cytokine pattern resemblant of cytokine release syndrome successfully treated with multimodal immunosuppression including tocilizumab
Author(s) -
Hellwig Yuliya,
Yoo Young E.,
Reß Marie L.,
Andres Oliver,
Braun Matthias,
Schlegel Paul G.,
Wölfl Matthias
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25595
Subject(s) - tocilizumab , medicine , fulminant , cytokine release syndrome , cytokine , immunosuppression , immunology , interleukin 6 , graft versus host disease , disease , immunotherapy , immune system , chimeric antigen receptor , rheumatoid arthritis
Acute Graft‐versus‐Host‐Disease (GvHD) is a potentially life‐threatening complication after allogeneic stem cell transplantation. If not treated early and adequately, the complex immunological mechanisms may lead to a self‐perpetuating cycle of alloreactivity, which is then associated with a high mortality. Here we assessed the cytokine profile on a daily basis in a patient with grade 4 skin GvHD, demonstrating a signature resembling cytokine‐release‐syndrome. After multimodal immunosuppressive intervention, including treatment with the IL6 receptor‐blocking antibody tocilizumab, the severe clinical symptoms unexpectedly resolved within 48hr. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.