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Renal medullary carcinoma and sickle cell trait: A systematic review
Author(s) -
Alvarez Ofelia,
Rodriguez Maria M.,
Jordan Lanetta,
Sarnaik Sharada
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25592
Subject(s) - medicine , sickle cell trait , medullary cavity , disease , renal cell carcinoma , abdominal pain , flank pain , surgery , pediatrics
Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N = 217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor‐related mortality was 95%. Four non‐metastatic patients were long‐term disease‐free survivors. Although risk appears to be very low , individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation. Pediatr Blood Cancer 2015;62:1694–1699. © 2015 Wiley Periodicals, Inc.