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Value of surgical resection in children with high‐risk neuroblastoma
Author(s) -
Englum Brian R.,
Rialon Kristy L.,
Speicher Paul J.,
Gulack Brian,
Driscoll Timothy A.,
Kreissman Susan G.,
Rice Henry E.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25504
Subject(s) - medicine , neuroblastoma , value (mathematics) , resection , surgical resection , oncology , general surgery , surgery , statistics , genetics , mathematics , biology , cell culture
Background The value of gross total resection (GTR) for children with high‐risk neuroblastoma (NB) is controversial. We hypothesized that patients undergoing GTR would demonstrate improved overall survival (OS) compared those having 90% resection compared to <90% resection ( P = 0.008). Multivariable Cox models confirmed these findings with improved survival in children undergoing >90% vs. <90% resection but no difference in GTR vs. 90% resection is associated with improved OS compared to less than 90% resection. Pediatr Blood Cancer 2015;62:1529–1535. © 2015 Wiley Periodicals, Inc.