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Extracorporeal photopheresis performed on the CELLEX® compared with the UVAR‐XTS® instrument is more efficient and better tolerated in children with steroid‐refractory graft‐versus‐host disease
Author(s) -
Kapadia Ekta,
Wong Edward,
PerezAlbuerne Evelio,
Jacobsohn David
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25487
Subject(s) - medicine , extracorporeal photopheresis , refractory (planetary science) , photopheresis , incidence (geometry) , extracorporeal , complication , graft versus host disease , surgery , disease , physics , astrobiology , optics
Abstract Extracorporeal photopheresis (ECP) is an effective therapy in children with refractory graft‐versus‐host disease (GVHD). The two most frequently used instruments are UVAR‐XTS® and CELLEX®. We performed a retrospective chart review of ten patients who underwent ECP with both UVAR‐XTS® and CELLEX® instruments for steroid‐refractory acute or chronic GVHD to compare instrument run times, percentages of cells treated, and complication rates. We found that compared to the UVAR‐XTS® instrument, use of the CELLEX® instrument resulted in shorter run times, increased percentage of mononuclear cells treated, reduced incidence of line occlusions requiring TPA treatment, and decreased incidence of patient‐related complications. Pediatr Blood Cancer 2015;62:1485–1488. © 2015 Wiley Periodicals, Inc.