Premium
Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B‐cell non‐Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)
Author(s) -
Sekimizu Masahiro,
Mori Tetsuya,
Kikuchi Akira,
Mitsui Tetsuo,
Sunami Shosuke,
Kobayashi Ryoji,
Fujita Naoto,
Inada Hiroko,
Takimoto Tetsuya,
Saito Akiko Moriya,
Watanabe Tomoyuki,
Fujimoto Junichiro,
Nakazawa Atsuko,
Ohshima Koichi,
Horibe Keizo,
Tsurusawa Masahito
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25482
Subject(s) - medicine , lymphoma , oncology , leukemia , lymphoblastic lymphoma , burkitt's lymphoma , pediatrics , immunology , t cell , immune system
Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B‐cell non‐Hodgkin lymphoma (B‐NHL). We performed a review of 79 abnormal karyotypes in childhood B‐NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event‐free survival in Burkitt or Burkitt‐like lymphoma. The adverse prognosis of MYC /8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B‐NHL. Pediatr Blood Cancer 2015;62:1294–1296. © 2015 Wiley Periodicals, Inc.