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Sickle cell in sickle cell disease in Latin America and the United States
Author(s) -
Huttle Alexandra,
Maestre Gladys E.,
Lantigua Rafael,
Green Nancy S.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25450
Subject(s) - latin americans , medicine , sickle cell trait , disease , population , fetal hemoglobin , epidemiology , sickle cell anemia , newborn screening , hemoglobinopathy , demography , pediatrics , environmental health , pregnancy , fetus , genetics , biology , sociology , philosophy , linguistics
Latin Americans are an underappreciated population affected by sickle cell disease (SCD). Sickle trait and SCD exist throughout Latin America and U.S. Latino communities. We describe the epidemiology and genetic heterogeneity of SCD among Latin Americans, and fetal hemoglobin expression. National population‐based newborn screening for SCD is limited to Brazil, Costa Rica, and the U.S. Available and extrapolated data suggest that over 6,000 annual births and 100,000–150,000 Latin Americans are affected by SCD. This comprehensive review highlights the substantial numbers and population distribution of SCD and sickle trait in Latin America, and where national newborn screening programs for SCD exist. Pediatr Blood Cancer 2015;62:1131–1136. © 2015 Wiley Periodicals, Inc.