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The associations between maternal factors during pregnancy and the risk of childhood acute lymphoblastic leukemia: A meta‐analysis
Author(s) -
Yan Kangkang,
Xu Xuejing,
Liu Xiaodong,
Wang Xikui,
Hua Shucheng,
Wang Chunpeng,
Liu Xin
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25443
Subject(s) - medicine , meta analysis , odds ratio , confidence interval , pregnancy , birth order , lymphoblastic leukemia , odds , medline , leukemia , pediatrics , obstetrics , logistic regression , environmental health , population , genetics , political science , law , biology
Background Although genetic and environmental factors are considered to be the main causes of acute lymphoblastic leukemia, the associations between maternal factors during pregnancy and the childhood ALL is still unclear. Procedure In this study, meta‐analysis was used. Medline, PubMed, and Web of Science were searched. The result was assessed based on pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results The pooled ORs showed that there were associations between childhood ALL and the birth order (The first vs others, OR = 1.08, 95%CI = 1.00–1.16), the education of pregnant woman (>high school vs ≤high school, OR = 0.82, 95%CI = 0.77–0.86), smoking (Ever vs never, OR = 1.10, 95%CI = 1.02–1.19). Conclusions Our meta‐analysis showed that there were important associations between childhood ALL and the birth order, the education of pregnant woman, smoking. Pediatr Blood Cancer 2015;62:1162–1170. © 2015 Wiley Periodicals, Inc.