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FN1: A novel fusion partner of ALK in an inflammatory myofibroblastic tumor
Author(s) -
Ouchi Kazutaka,
Miyachi Mitsuru,
Tsuma Yusuke,
Tsuchiya Kunihiko,
Iehara Tomoko,
Konishi Eiichi,
Yanagisawa Akio,
Hosoi Hajime
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25424
Subject(s) - anaplastic lymphoma kinase , fusion gene , medicine , cancer research , pathology , gene , lung cancer , biology , genetics , malignant pleural effusion
Inflammatory myofibroblastic tumors (IMTs) are rare tumors characterized as low‐to‐intermediate grade sarcomas. Rearrangements of the anaplastic lymphoma kinase ( ALK ) gene have been reported in IMT. Here, we describe a novel fusion gene in an IMT tumor specimen. A 12‐year‐old male was admitted to our hospital with a bladder tumor. We identified the fibronectin 1 gene ( FN1 ) as a fusion partner of ALK using 5′RACE. This novel fusion, FN1–ALK , resulted in ALK overexpression in the IMT. This finding should clarify the causes of IMT and facilitate development of novel therapeutics. Pediatr Blood Cancer 2015;62:909–911. © 2015 Wiley Periodicals, Inc.