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Oral leukoplakia in patients with Fanconi anaemia without hematopoietic stem cell transplantation
Author(s) -
Grein Cavalcanti Laura,
Lyko Karine Fátima,
Araújo Renata Lins Fuentes,
Amenábar José Miguel,
Bonfim Carmem,
TorresPereira Cassius Carvalho
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25417
Subject(s) - medicine , oral mucosa , leukoplakia , fanconi anemia , hematopoietic stem cell transplantation , dyskeratosis congenita , dermatology , transplantation , bone marrow failure , pathology , gastroenterology , cancer , stem cell , haematopoiesis , dna repair , dna , biochemistry , chemistry , genetics , telomere , biology , gene
Background Fanconi anaemia is a genetic disease characterized by congenital abnormalities, progressive bone marrow failure, and a higher predisposition of oral squamous cell carcinoma. The purpose of this study was to evaluate the prevalence of oral mucosa lesions in patients with Fanconi anaemia without hematopoietic stem cell transplantation (HSCT). Procedure Patients with Fanconi anaemia who had not undergone HSCT was cross‐sectional evaluated for the presence of oral lesions. Results The sample was composed of 78 male and 60 female patients, with a median age of 9 years. Of the 138 patients, approximately 45% manifested at least one oral mucosa abnormality: 35 patients (25%) presented with traumatic injuries, and 16 (12%) exhibited leukoplakia. The following lesions were observed in low prevalence: aphthous ulcers, atrophic tongue, petechiae and hematomas, gingival hyperplasia, mucoceles, herpes, hyperpigmentation, haemangioma, non‐neoplastic proliferative lesions, neutropenic ulcers, papilloma, and candidiasis. Conclusion There was a high prevalence of oral leukoplakias in patients with Fanconi anaemia who had not undergone HSCT. It highlights the need of regular oral screenings in this cohort of concern for head and neck malignancies and suggests that oral leukoplakias should be further investigated as part of the syndrome phenotype. Pediatr Blood Cancer 2015;62:1024–1026. © 2015 Wiley Periodicals, Inc.