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Red cell exchange transfusion halts progressive proliferative sickle cell retinopathy in a teenaged patient with hemoglobin SC disease
Author(s) -
McKinney Christopher M.,
Siringo Frank,
Olson Jeffrey L.,
Capocelli Kelly E.,
Ambruso Daniel R.,
Nuss Rachelle
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25397
Subject(s) - medicine , vitrectomy , vitreous hemorrhage , exchange transfusion , ophthalmology , retinopathy , pars plana , retinal detachment , disease , cell , retinal , surgery , pediatrics , pathology , visual acuity , endocrinology , diabetes mellitus , biology , genetics
A male with sickle SC disease presented at age 8 years with proliferative sickle cell retinopathy (PSCR) and bilateral vitreous hemorrhage which spontaneously resolved, then recurred at 13 years of age. Despite conventional therapy with repeated pan‐retinal photocoagulation and pars plana vitrectomy, he developed progressive PSCR and recurrent vitreous hemorrhage over the next 30 months. We describe the successful use of chronic red cell exchange transfusion (RCE) to preserve his vision and stabilize the retinopathy. Pediatr Blood Cancer 2015;62:721–723. © 2015 Wiley Periodicals, Inc.